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A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance. Provided as lyophilized powder, choose from standard or custom pack sizes. Browse our featured list of RUO-grade below and learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kit is comprised of the small molecules used in the CEPT method: Chroman 1, Emricasan, and Trans-IRIB (CET). As the first to market, the CET Cocktail Kit enhances stem cell survival and address the key challenges in cell recovery.
The CET Cocktail Kit can be used for routine long-term passaging, cryopreservation, single-cell cloning, and organoid formation.
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A83-01 has been extensively used in various studies to modulate TGF-β signaling pathways, impacting cellular differentiation, organoid growth, and disease modeling. A83-01 is supplied as a lyophilized powder.
Captivate Bio's A83-01 (GMP-grade) is a small-molecule inhibitor that blocks the activity of certain receptors in the transforming growth factor-beta (TGF-β) signaling pathway, specifically ALK5, ALK4, and ALK7, ideal for cell therapy applications.
Captivate Bio's ACY Cocktail Kit is a combination of three small molecules optimized to enhance cell proliferation, viability, and stemness in MSC stem cell cultures and organoid research.
AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 is supplied as a lyophilized powder.
BIO is a potent ATP-competitive GSK-3 inhibitor that maintains self-renewal and pluripotency in hESCs, also promotes proliferation and differentiation in cardiomyocytes. Lyophilized powder.
BIRB796 is a highly potent inhibitor of p38 MAPK that enhances stem cell activity of cultured umbilical cord blood-derived hematopoietic cells. BIRB796 can be used in protocols for the chemical reprogramming of somatic cells to iPSCs.
Captivate Bio's newly optimized CET Cocktail Kits are designed to enhance cell survival and promote growth of genetically stable hPSCs. Kits are configured to address specific workflows. Three versions include: CET Spark™ for 1L, CET Ignite™ for 5L, and CET Titan™ for 20L or more.
CHIR99021 potentiates self-renewal of human and mouse embryonic stem cells and enhances reprogramming of somatic cells into stem cells and also augments the differentiation potential of MSCs. Available as a lyophilized powder and in RUO or GMP-grade formats.
CHIR99021 (GMP-grade) promotes self-renewal and pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). It can also maintain stem cells in an undifferentiated state and guide differentiation into specific lineages. Produced under GMP guidelines and is ideal for cell therapy research.
Highly potent and selective ROCK inhibitor with greater effectiveness at lower doses than Y27632. Enhances cell survival of dissociated hPSCs.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
