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A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance. Provided as lyophilized powder, choose from standard or custom pack sizes. Browse our featured list of RUO-grade below and learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kits are designed to minimize cellular stress and maximize stem cell survival across critical workflows. Featuring the powerful CET combination of Chroman 1, Emricasan, and Trans-ISRIB, our first-to-market kit helps researchers overcome key challenges associated with cell recovery, passaging, cryopreservation, single-cell cloning, and organoid formation.
Built to support the demanding needs of modern stem cell research, we have three different CET Cocktail Kits designed to help you improve cell viability and workflow performance. Our CET SparkTM, CET IgniteTM, and CET TitanTM kits deliver a smarter approach to stem cell survival production.
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Compound E is a γ-secretase and notch patchway inhibitor which induces neuronal differentiation. Compound E enhances growth inhibition, differentiation, and migration of neuroblastoma cells.
Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.
DAPT is a gamma γ-secretase inhibitor induces neuronal differentiation and promotes differentiation of pancreatic cells from hPSCs.
DAPT (GMP-grade) is a gamma γ-secretase inhibitor induces neuronal differentiation and promotes differentiation of pancreatic cells from hPSCs. This small molecule is produced under GMP guidelines and is ideal for cell therapy research.
DBZ is an inhibitor of γ-secretase aspartyl protease that improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC.
Dexamethasone is commonly used to stimulate osteogenic differentiation of mesenchymal stem/stromal cells (MSCs) in vitro.
Dorsomorphin is a small molecule widely used in cell culture as a selective inhibitor of BMP signaling. Dorsomorphin is particularly useful in early-stage stem cell differentiation studies to direct cells toward specific lineages, such as cardiac or neural.
EC23 (AGN 190205) is a stable synthetic retinoid analogue and induces neuronal differentiation.
Emricasan is an irreversible pan-caspase inhibitor. A key small molecule component of the published CEPT cocktail, enhances cell survival, clonogenicity, and cytoprotection of hPSCs.
Forskolin is a cell-permeable diterpene that directly activates adenylyl cyclase, for the maintenance and reprogramming of stem cells.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
