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Small molecules are increasingly being used as tools to modulate signaling pathways and understand stem cell biology. As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents. GMP small molecules reduce the risk of unwanted genetic material, are easily scalable, and are manufactured following ICH Q7 guidelines.
For over a decade, the Captivate Bio team has been supporting Cell and Gene Therapy development programs, from transitioning to GMP-grade reagents and bulk supply contracts, to project planning, we can guide you every step of the way. Contact us today to kick off the conversation.
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An important consideration when developing a cell therapy is deciding to change from RUO-grade to GMP-grade reagents. Although the quality of the reagent should be similar, GMP-grade reagents provide enhanced quality testing and tighter manufacturing specifications. We recommend identifying primary and secondary suppliers early on in your research, who can support your preclinical development as you look to move from RUO to GMP. GMP compounds are synthesized under a quality assured manufacturing system and subjected to stringent quality control following cGMP guidelines.
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Captivate Bio's A83-01 (GMP-grade) is a small-molecule inhibitor that blocks the activity of certain receptors in the transforming growth factor-beta (TGF-β) signaling pathway, specifically ALK5, ALK4, and ALK7, ideal for cell therapy applications.
CHIR99021 (GMP-grade) promotes self-renewal and pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). It can also maintain stem cells in an undifferentiated state and guide differentiation into specific lineages. Produced under GMP guidelines and is ideal for cell therapy research.
DAPT (GMP-grade) is a gamma γ-secretase inhibitor induces neuronal differentiation and promotes differentiation of pancreatic cells from hPSCs. This small molecule is produced under GMP guidelines and is ideal for cell therapy research.
L-Ascorbic Acid (GMP-grade), also known as Vitamin C, enhances the generation of iPSCs and increases reprogramming efficiency. This molecule is manufactured under cGMP guidelines making them ideal for cell therapy applications.
LDN193189 (GMP-grade) is a potent inhibitor of the BMP pathway, shown to contribute to the differentiation of pluripotent stem cells into functional pancreatic beta cells. This small molecule is produced under GMP guidelines and is used in cell therapy applications.
PD0325901 (GMP-grade) is a potent, selective, and orally available inhibitor of MEK1/2, a protein crucial for the MAPK signaling pathway that regulates cell growth and proliferation. This small molecule is produced under cGMP and is ideal for cell therapy applications.
Purmorphamine (GMP-grade), a hedgehog pathway activator, has been shown to promote differentiation of motor neurons from human pluripotent stem cells and human and mesenchymal stem cells. This product is manufactured under cGMP and is ideal for cell therapy applications.
RepSox (GMP-grade) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. This small molecule is produced under cGMP guidelines and is ideal for cell therapy research.
Retinoic Acid (GMP-grade) is used for the differentiation of embryonic stem cells into motor neurons and human pluripotent stem cells (PSCs) into functional pancreatic β cells. This small molecule is produced under cGMP guidelines and is ideal for cell therapy applications.
SANT-1 is a potent antagonist that aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (hPSCs). This product is manufactured under cGMP and is ideal for cell therapy applications.
Sourcing the right reagents or hard-to-find small molecules can be difficult and time-consuming. Captivate Bio can save you time by simplifying the sourcing of FBS, Human Platelet Lysate, classical media, small molecules, cytokines, and growth factors that meet your requirements, timeline, and budget. Let Captivate Bio be your first stop in providing access to thousands of research and GMP-grade reagents.
Contact us today to get started.
