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A 419259

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A 419259 trihydrochloride is a potent Hck inhibitor that supresses proliferation and induces apoptosis in CML cell lines including CD34+ also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

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SKUSIZEPRICE QTY
SML50B10 mg
$425.00
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SML50C50 mg
$1,155.00
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SKUSML50
FormPowder
GradeRUO
Alternative NamesRK-20449, A-419259, A419259
Chemical Name7-[trans-4-(4-Methyl-1-piperazinyl)cyclohexyl]-5-(4-phenoxyphenyl)-7H-Pyrrolo[2,3-d]pyrimidin-4-amine trihydrochloride
Chemical FormulaC29H34N6O
Molecular Weight482.63
CAS Number364042-47-7
PubChem ID76848881
SMILES NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C= C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1
Physical AppearanceWhite to light yellow
TargetProtein Tyrosine Kinase/RTK; Apoptosis
ShippingAMB

A 419259 trihydrochloride is a potent Hck inhibitor that supresses proliferation and induces apoptosis in CML cell lines including CD34+ also inhibits acute myeloid leukemia (AML) stem cell proliferation in vitro and in vivo.

Resources
References and Publications

  1. Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.
  2. Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89.

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