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AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 is supplied as a lyophilized powder.
AM 80 is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 μM respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. AM 80 is a cell cycle activator in hiPSC-derived cardiomyocytes, and pretreatment with AM 80 promotes engraftment of cardiomyocytes in mice with heart damage.
Applications: Cancer research: targeting kinases (like EGFR, KRAS, JAK), lung cancer, leukemia, breast cancer, inflammatory and autoimmune Diseases, DNA Repair
Keywords: AM 80, AM 80 supplier, RARα, RARalpha, agonists, anticancer, Retinoic, Acid, Receptors, AM80, cardiomyocytes, cell, activators, activation, Tamibarotene, Cardiomyocyte, small molecules
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