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A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance. Provided as lyophilized powder, choose from standard or custom pack sizes. Browse our featured list of RUO-grade below and learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kit is comprised of the small molecules used in the CEPT method: Chroman 1, Emricasan, and Trans-IRIB (CET). As the first to market, the CET Cocktail Kit enhances stem cell survival and address the key challenges in cell recovery.
The CET Cocktail Kit can be used for routine long-term passaging, cryopreservation, single-cell cloning, and organoid formation.
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SB203580 is a selective ATP-competitive p38 MAPK inhibitor. Enhances the growth of mouse ES cells and enhances differentiation of cardiomyocytes from human ES cells.
SB431542 is a potent small molecule inhibitor of TGF-β signaling. Used for hESC neural differentiation and enhanced differentiation of PSCs into cardiomyocytes. Replaces SOX2 in reprogramming of fibroblasts into iPSCs.
SB431542 (GMP-grade) is a potent small molecule inhibitor used for hESC neural differentiation and enhanced differentiation of PSCs into cardiomyocytes. Produced under GMP guidelines and is ideal for cell therapy research.
StemRegenin 1 or SR1 is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes the expansion human hematopoietic stem cells and the generation of progenitor cells. This small molecule is available in custom pack sizes.
StemRegenin 1 or SR1 (GMP-grade) is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes the expansion human hematopoietic stem cells and the generation of progenitor cells. This product is GMP-grade and can be used in cell and gene therapy research applications. Bulk discounts and custom packaging available.
SU5402 is a potent and selective inhibitor of VEGFR-2, FGFR-1, and PDGFRB.
Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. Improves the efficiency of fibroblast reprogramming and induction of iPSCs.
Thiazovivin (GMP-grade) is a novel ROCK inhibitor that promotes hESC survival after single-cell dissociation. Improves the efficiency of fibroblast reprogramming and induction of iPSCs. This small molecule is produced under GMP guidelines making it ideal for cell therapy research.
TPPB is a small molecule activator of protein kinase C, also known as α-amyloid precursor protein (APP) modulator or TBP.
An integrated stress response (ISR) inhibitor that promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 and Emricasan small molecules in the CEPT cocktail1.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
