JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s growing portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance.
Browse below or learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kits are designed to minimize cellular stress and maximize stem cell survival across critical workflows. Featuring the powerful CET combination of Chroman 1, Emricasan, and Trans-ISRIB, our first-to-market kits help researchers overcome key challenges associated with cell recovery, cryopreservation, single-cell cloning, and organoid formation.
Built to support the demanding needs stem cell researchers, we have three different CET Cocktail Kits designed to help you improve cell viability and workflow performance. Our CET SparkTM, CET IgniteTM, and CET TitanTM Cocktail kits deliver a smarter approach to stem cell survival production.
Items 41-50 of 65
Retinoic Acid is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors. Retinoic Acid has been used for the differentiation of embryonic stem cells into motor neurons and has also played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells.
Retinoic Acid (GMP-grade) is used for the differentiation of embryonic stem cells into motor neurons and human pluripotent stem cells (PSCs) into functional pancreatic β cells. This small molecule is produced under cGMP guidelines and is ideal for cell therapy applications.
SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM). SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs).
SANT-1 is a potent antagonist that aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (hPSCs). This product is manufactured under cGMP and is ideal for cell therapy applications.
Potent and selective GSK3 inhibitor (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC50 > 10 μM). Stimulates glycogen synthesis, gene transcription and is cardio- and neuroprotective.
SB203580 is a selective ATP-competitive p38 MAPK inhibitor. Enhances the growth of mouse ES cells and enhances differentiation of cardiomyocytes from human ES cells.
SB431542 is a potent small molecule inhibitor of TGF-β signaling. Used for hESC neural differentiation and enhanced differentiation of PSCs into cardiomyocytes. Replaces SOX2 in reprogramming of fibroblasts into iPSCs.
SB431542 (GMP-grade) is a potent small molecule inhibitor used for hESC neural differentiation and enhanced differentiation of PSCs into cardiomyocytes. Produced under GMP guidelines and is ideal for cell therapy research.
StemRegenin 1 or SR1 is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes the expansion human hematopoietic stem cells and the generation of progenitor cells. This small molecule is available in custom pack sizes.
StemRegenin 1 or SR1 (GMP-grade) is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes the expansion human hematopoietic stem cells and the generation of progenitor cells. This product is GMP-grade and can be used in cell and gene therapy research applications. Bulk discounts and custom packaging available.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
