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AGN 193109

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AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist. For cancer research, organoids, and stem cell differentiation, Captivate Bio's AGN 193109 is available in multiple pack sizes.

Grouped product items
SKUSIZEPRICE QTY
SML48B10 mg
$400.00
- +
SML48C50 mg
$950.00
- +
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Description
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More Information
SKUSML48
FormPowder
GradeRUO
Chemical Name4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid
Chemical FormulaC28H24O2
Molecular Weight392.49
CAS Number171746-21-7
PubChem ID177238
SMILESO=C(O)C1=CC=C(C#CC2=CC=C3C(C)(C)CC=C(C4=
CC=C(C)C=C4)C3=C2)C=C1
Physical AppearanceWhite to light yellow
ShippingAMB
Storage- 20°C

AGN 193109 is a high affinity pan-retinoic acid receptor (RAR) antagonist (Kd values are 2, 2 and 3 nM at RARα, RARβ and RARγ). Exhibits no significant affinity for retinoic X receptors. AGN 193109 promotes the differentiation from mouse embryonic stem cells. AGN 193109 suppresses primary human cardiovascular smooth muscle cell calcification.

Alternative names: RAR antagonist
Applications: Pluripotent Stem Cells; cancer stem cell research
Cell types: epithelial cells, organoids, neural stem cells

Resources
References and Publications

  • Cell Rep Med. 2026 Apr 21;7(4):102698.
  • Redox Biol. 2024 Nov:77:103361.
  • Cancer Res. 2023 Jul 14;83(14):2387-2404.
  • Allergy. 2022 Feb;77(2):483-498.
  • Sci Adv. 2020 Nov 4;6(45):eaaz1410.
  • Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12.
  • Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75.
  • Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7.

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