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Triiodothyronine Salt is an analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1). Regulates functions such as growth, metabolic activity, and hPSC differentiation. Stimulates respiratory activity at the mitochondrial level.
Triiodothyronine Salt (or Liothyronine sodium/3,3’,5-Triiodo-L-thyronine sodium) is an analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1). This binding, in turn, regulates functions such as growth, metabolic activity, and differentiation (Bhat, et al.). Triiodothyronine Salt has been shown to promote enhanced maturation of cardiomyocyte populations, to the extent that beating cardiomyocytes may be maintained for up to six months (Burridge, et al.), in addition to playing a role in the induction of pluripotent stem cells from human keratinocytes (Aasen & Belmonte).
Triiodothyronine Salt Technical Data Sheet
Triiodothyronine Salt SDS
Brochure: Small Molecules for Stem Cell Research
FAQs: General Guide for Small Molecules
Aasen & Belmonte. 2010. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nature Protocols. 5: 371-382.
Bhat, et al. 1993. Conformational changes of human β1 thyroid hormone receptor induced by binding of 3,3’,5-Triiodo-L-thyronine. BiochemBiophys Res Commun. 195(1): 385-392.
Burridge, et al. 2015. Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells. Curr Protoc Hum Genet. 87(1): 1-15.
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