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A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s growing portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance.
Browse below or learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kits are designed to minimize cellular stress and maximize stem cell survival across critical workflows. Featuring the powerful CET combination of Chroman 1, Emricasan, and Trans-ISRIB, our first-to-market kits help researchers overcome key challenges associated with cell recovery, cryopreservation, single-cell cloning, and organoid formation.
Built to support the demanding needs stem cell researchers, we have three different CET Cocktail Kits designed to help you improve cell viability and workflow performance. Our CET SparkTM, CET IgniteTM, and CET TitanTM Cocktail kits deliver a smarter approach to stem cell survival production.
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LDN193189 (GMP-grade) is a potent inhibitor of the BMP pathway, shown to contribute to the differentiation of pluripotent stem cells into functional pancreatic beta cells. This small molecule is produced under GMP guidelines and is used in cell therapy applications.
N-Acetyl-L-cysteine (NAC) is a cell-permeable small molecule used in cell culture as an antioxidant and a precursor to glutathione. It protects cells from oxidative stress by scavenging reactive oxygen species (ROS) and supporting cellular redox balance.
Captivate Bio's Neuro Cocktail Kit delivers the essential small molecules needed for robust neuronal differentiation, minimizing variability and simplifying protocol setup with six trusted, high-quality components.
Captivate Bio's Nicotinamide is a form of vitamin B3 or niacin, suitable for insect cultures, as well as boosts stem cell survival and expansion of hematopoietic stem cells (HSPCs). Lyophilized powder.
PD0325901 is a selective, non-ATP-competitive inhibitor of the mitogen-activated protein kinase (MAPK/ERK kinase, or MEK) that suppresses expression of p-ERK1/2 and induces apoptosis. PD0325901 enhances generation of induced pluripotent stem cells (iPSCs).
PD0325901 (GMP-grade) is a potent, selective, and orally available inhibitor of MEK1/2, a protein crucial for the MAPK signaling pathway that regulates cell growth and proliferation. This small molecule is produced under cGMP and is ideal for cell therapy applications.
Hedgehog pathway activator; Activates Smoothened (SMO). Purmorphamine has been shown to promote differentiation of motor neurons from human pluripotent stem cells and human and mouse mesenchymal stem cells.
Purmorphamine (GMP-grade), a hedgehog pathway activator, has been shown to promote differentiation of motor neurons from human pluripotent stem cells and human and mesenchymal stem cells. This product is manufactured under cGMP and is ideal for cell therapy applications.
RepSox is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox was found to replace the function of Sox2 to induce reprogramming of iPS cells.
RepSox (GMP-grade) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. This small molecule is produced under cGMP guidelines and is ideal for cell therapy research.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
