A83-01 (GMP)

Captivate Bio offers a portfolio of GMP-grade small molecules. GMP-grade small molecules are produced under well establish, controlled cGMP guidelines and are used as ancillary reagents in the generation of stem cells and in reprogramming, self-and differentiation workflows for cell therapy applications.

A83-01 is a small-molecule inhibitor that blocks the activity of certain receptors in the transforming growth factor-beta (TGF-β) signaling pathway, specifically ALK5, ALK4, and ALK7. This inhibition disrupts Smad signaling and suppresses epithelial-to-mesenchymal transition (EMT), and it has been used in research for stem cell reprogramming and studies on cancer, fibrosis, and wound healing.

Accelerating Cell Therapy Research Programs

As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents.

GMP Features

• Enhanced quality testing and documentation
• High purity and consistent activity
• Reduce risk of unwanted genetic material
• Easily scalable, available in large volumes
• Manufactured following ICH Q7 guidelines

Quality Assurance

• QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
• Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

Fun Fact: A fun fact about A83-01 is that this small molecule is a highly selective "brake" for specific cell-signaling pathways (ALK4, ALK5, ALK7) that drive unwanted cell changes or spontaneously differentiating, making A83-01 super useful for stabilizing pluripotent stem cells and helping scientists grow more stem cells (clonal expansion).

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