Thiazovivin

Thiazovivin is a potent and selective inhibitor of Rho kinase (ROCK) activity, a key player in cytoskeletal contraction and rearrangement. As ROCK inhibition occurs, human embryonic stem cell survival increases through enhanced cell-ECM attachment via E-cadherin signaling (Xu, et al.), in addition to allowing for an environment for improved human iPSCs from fibroblasts when used in combination with ALK5 inhibitor SB 431542 and MEK inhibitor PD0325901 (Lin, et al.). The addition of Thiazovivin also creates more effective conditions for the reprogramming of cord blood mononuclear cells into iPSCs (Hu, et al.).

Applications: cellular reprogramming, mouse embryonic fibroblasts into chemically induced neural stem cells, improves the efficiency of iPSC generation
Molecular name: Thiazovivin, ROCK inhibitor
Purity: Greater than 95% by LCMS

Keywords: Thiazovivin, Thiazovivin supplier, stem cells, reprogramming, dedifferentiation, induced pluripotent stem cells, ipscs, hesc, neural, fibroblasts, reprogramming, rho-kinases, cell proliferation

Documents

• Technical Data Sheet
• SDS
• Brochure: Small Molecules for Stem Cell Research
• FAQs: General Guide for Small Molecules

References and Publications

1. Hu, et al. 2011. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 117(14): 109-119.
2. Lin, et al. 2009. A chemical platform for improved induction of human iPSCs. Nature Methods. 6: 805-808.
3. Xu, et al. 2010. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.