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A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance. Provided as lyophilized powder, choose from standard or custom pack sizes. Browse our featured list of RUO-grade below and learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kits are designed to minimize cellular stress and maximize stem cell survival across critical workflows. Featuring the powerful CET combination of Chroman 1, Emricasan, and Trans-ISRIB, our first-to-market kit helps researchers overcome key challenges associated with cell recovery, passaging, cryopreservation, single-cell cloning, and organoid formation.
Built to support the demanding needs of modern stem cell research, we have three different CET Cocktail Kits designed to help you improve cell viability and workflow performance. Our CET SparkTM, CET IgniteTM, and CET TitanTM kits deliver a smarter approach to stem cell survival production.
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IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP-2 has also been used in protocols to reprogram somatic cells to chemically-induced PSCs.
IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 is used in the research of neural research, Alzheimer’s disease, and various cancers.
L-Ascorbic Acid enhances the generation of iPSCs and increases reprogramming efficiency.
L-Ascorbic Acid (GMP-grade), also known as Vitamin C, enhances the generation of iPSCs and increases reprogramming efficiency. This molecule is manufactured under cGMP guidelines making them ideal for cell therapy applications.
LDN193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor. LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, shown to contribute to the differentiation of pluripotent stem cells into functional pancreatic beta cells.
LDN193189 (GMP-grade) is a potent inhibitor of the BMP pathway, shown to contribute to the differentiation of pluripotent stem cells into functional pancreatic beta cells. This small molecule is produced under GMP guidelines and is used in cell therapy applications.
Captivate Bio's Neuro Cocktail Kit delivers the essential small molecules needed for robust neuronal differentiation, minimizing variability and simplifying protocol setup with six trusted, high-quality components.
Captivate Bio's Nicotinamide is a form of vitamin B3 or niacin, suitable for insect cultures, as well as boosts stem cell survival and expansion of hematopoietic stem cells (HSPCs). Lyophilized powder.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
