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A growing number of small molecules have been identified for the growth, maintenance, and differentiation of ESCs, iPSCs, PSCs, MSCs, and hematopoietic stem cells. Captivate Bio’s growing portfolio of high quality small molecules are powerful tools capable of modulating and fine-tuning key pathways. All our small molecules are extensively tested to ensure high purity, biological activity, and stability for optimal performance.
Browse below or learn more about our GMP-grade small molecules here.
A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.
Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632
Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.
Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632
Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.
Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin
Captivate Bio’s CET Cocktail Kits are designed to minimize cellular stress and maximize stem cell survival across critical workflows. Featuring the powerful CET combination of Chroman 1, Emricasan, and Trans-ISRIB, our first-to-market kits help researchers overcome key challenges associated with cell recovery, cryopreservation, single-cell cloning, and organoid formation.
Built to support the demanding needs stem cell researchers, we have three different CET Cocktail Kits designed to help you improve cell viability and workflow performance. Our CET SparkTM, CET IgniteTM, and CET TitanTM Cocktail kits deliver a smarter approach to stem cell survival production.
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SU5402 is a potent and selective inhibitor of VEGFR-2, FGFR-1, and PDGFRB.
Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. Improves the efficiency of fibroblast reprogramming and induction of iPSCs.
Thiazovivin (GMP-grade) is a novel ROCK inhibitor that promotes hESC survival after single-cell dissociation. Improves the efficiency of fibroblast reprogramming and induction of iPSCs. This small molecule is produced under GMP guidelines making it ideal for cell therapy research.
TPPB is a small molecule activator of protein kinase C, also known as α-amyloid precursor protein (APP) modulator or TBP.
An integrated stress response (ISR) inhibitor that promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 and Emricasan small molecules in the CEPT cocktail1.
Liothyronine (Triiodothyronine) is an active form of thyroid hormone, this molecule selectively binds and activates β1 thyroid hormone receptor (TRβ1). Also regulates growth, metabolic activity, and hPSC differentiation. This small molecule is produced under GMP guidelines and is ideal for cell therapy research.
Liothyronine sodium is an active form of thyroid hormone, also named Triiodothyronine Salt, this molecule selectively binds and activates β1 thyroid hormone receptor (TRβ1). Also regulates growth, metabolic activity, and hPSC differentiation.
Trolox is an analogue of vitamin E with a powerful antioxidant effect. Trolox is also a powerful inhibitor of membrane damage.
TTNPB is an extremely potent analog of retinoic acid, selective for the retinoic acid receptor (RAR) subtype. Enhances reprogramming efficiency in chemically induced pluripotent stem cells (iPSCs).
Highly potent PORCN inhibitor, Wnt-C59 is used to generate B cells from human PSCs, induce neural differentiation and cardiomyocyte differentiation.
As your research program advances into therapeutic discovery, making the transition from RUO-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can support this transition easier with our newly released GMP-grade small molecules for the production of MSCs, hPSCs, NK cells, and more.
With enhanced quality testing and documentation, all our GMP Small Molecules are produced in strict accordance under controlled cGMP guidelines, assuring safe, reliable, and consistent ancillary reagents.
