Purmorphamine

Purmorphamine is a tri-substituted purine derivative that activates the Hedgehog pathway by directly binding to and activating the Hedgehog receptor Smoothened. Purmorphamine has been shown to promote differentiation of motor neurons from human pluripotent stem cells (Hu, et al., Li, et al.) and the differentiation of adipocytes and osteoblasts from human and mouse mesenchymal stem cells (Beloti, et al., Wu, et al., Fontaine et al.)

Applications: Differentiation, Neuroscience, Stem Cell Biology
Cell types: Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Osteoblasts, Pluripotent Stem Cells

Keywords: Purmorphamine, Purmorphamine supplier, Smoothened, Smo, receptors, agonists, differentiation, multipotent, mesenchymal, progenitor, cells, osteoblasts, osteogenic, Receptors, Mesenchymal Stem Cells

References & Publications

• Gu D, et al. A role for transcription factor STAT3 signaling in oncogene smoothened-driven carcinogenesis. J Biol Chem. 2012 Nov 2;287(45):38356-66.
• Sinha, et al. Purmorphamine activates the Hedgehog pathway by targeting Smoothened. 2006 Nat.Chem.Biol. 2 29 PMID: 16408088
• Beloti, MM, et al. Purmorphamine enhances osteogenic activity of human osteoblasts derived from bone marrow mesenchymal cells. Cell Biol Int. 2005 Jul;29(7):537-41