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RepSox (GMP)

RepSox (GMP-grade) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. This small molecule is produced under cGMP guidelines and is ideal for cell therapy research.

Grouped product items
SKU	SIZE	PRICE	QTY
SML06BG	10 mg	$1,100.00	- +
SML06KG	50 mg	$3,300.00	- +

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Description

Specifications

More Information
SKU	SML06GMP
Molecular Name	RepSox
Form	Powder
Grade	GMP-grade
Alternative Names	ALK5 inhibitor II, ALK5 Inhibitor, ALK5i, E-616452, SJN2511
Chemical Name	2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Chemical Formula	C₁₇H₁₃N₅
Molecular Weight	287.32
CAS Number	446859-33-2
SMILES	CC1=NC(C2=NNC=C2C3=NC4=CC=CN=C4C=C3) =CC=C1
Purity	Greater than 95% by LCMS
Physical Appearance	Light yellow to yellow (Solid)
Target	TGF-β Receptor
Shelf-Life	≥ 2 years (powder)
Shipping	Room Temperature
Quality Statement	This product is for Research Use Only and is not intended for therapeutic or diagnostic use.

Captivate Bio offers a portfolio of GMP-grade small molecules. GMP-grade small molecules are produced under well establish, controlled cGMP guidelines and are used as ancillary reagents in the generation of stem cells and in reprogramming, self-and differentiation workflows for cell therapy applications.

RepSox is a potent and selective inhibitor of the TGF-β type 1 receptor (TGFβRI)/ALK5 that exhibits cell permeability and specifically inhibits ALK5 autophosphorylation with IC50 of 4 nM. When used in conjunction with CHIR99021, LDN193189, and Y27632, among others, RepSox aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.).

RepSox has also been shown to contribute to the reprogramming of mouse embryonic fibroblasts to iPSCs (Subramanyam, et al.), in addition to the induction of human fibroblasts into neuronal cells for research on Alzheimer’s disease (Hu, et al). It has also been used as a basal media component for culturing human pluripotent stem cells.

Key Applications:

Cellular reprogramming: RepSox can replace the need for the SOX2 gene when inducing pluripotency in adult cells.
Adipogenesis: It can induce brown fat formation and "browning" of white fat cells, which may have therapeutic potential for obesity and type 2 diabetes.
Cancer research: It has been studied for its ability to induce apoptosis in osteosarcoma cells and suppress tumor growth.
Tissue differentiation: It can support the differentiation of retinal pigmented epithelium (RPE) cells from induced pluripotent stem cells (iPSCs).

GMP Features

Enhanced quality testing and documentation
High purity and consistent activity
Reduce risk of unwanted genetic material
Easily scalable, available in large volumes
Manufactured following ICH Q7 guidelines

Quality Assurance

QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

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