LDN193189 (GMP)

Captivate Bio offers a portfolio of GMP-grade small molecules. GMP-grade small molecules are produced under well establish, controlled cGMP guidelines and are used as ancillary reagents in the generation of stem cells and in reprogramming, self-and differentiation workflows for cell therapy applications.

LDN193189 (HCl) is a highly-potent inhibitor of BMP signaling, specifically blocking ALK1 (IC50 of 0.8 nM), ALK2 (IC50 of 0.8 nM), ALK3 (IC50 of 5.3 nM), and ALK6 (IC50 of 16.7 nM), and in turn affecting Smad1/5/8 expression (Galvin-Burgess, et al.). LDN193189 (HCl) has been shown to contribute to the differentiation of pluripotent stem cells (PSCs) into functional pancreatic beta cells when combined with CHIR99021, SANT-1, Y27632, Compound E, RepSox, Triiodothyronine Salt along with other growth factors (Pagliuca, et al.). LDN193189 has also been utilized in the derivation of neural progenitor cells (Edri, et al.), and cortical neurons (Qi, et al.) from PSCs.

Cell Types: Adipocytes, Cancer Cells and Cell Lines, Mammary Cells, Neural Cells, PSC-Derived, Pluripotent Stem Cells, Prostate Cells
Applications: Differentiation, Maintenance, Stem Cells, Neuroscience

Accelerating Cell Therapy Research Programs

As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents.

GMP Features

• Enhanced quality testing and documentation
• High purity and consistent activity
• Reduce risk of unwanted genetic material
• Easily scalable, available in large volumes
• Manufactured following ICH Q7 guidelines

Quality Assurance

• QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
• Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

Keywords: LDN193189 (GMP), TGF-β Receptor, Transforming growth factor beta receptors, bone morphogenetic protein (BMP), BMP, receptor, transcription, ALK2, ALK3, bone morphogenetic protein signaling, cell therapy, stem cells, neurons