SB431542 (GMP)

Captivate Bio offers a portfolio of GMP-grade small molecules. GMP-grade small molecules are produced under well establish, controlled cGMP guidelines and are used as ancillary reagents in the generation of stem cells and in reprogramming, self-and differentiation workflows for cell therapy applications.

SB431542, GMP is a highly-potent and -selective inhibitor of the TGF-β type I receptor, with specific inhibition of ALK5 (IC50 of 94 nM) and its closest relatives ALK4 and ALK7 as part of the TGF-β/Activin/Nodal pathway. SB431542 has been shown to be a highly efficient additive for inducing neural differentiation of embryonic stem cells (ESCs) in a rapid manner when combined with Noggin (Chambers, et al.), or Noggin and LDN193189 (Edri, et al.), promoting the self-renewal of primitive neuroepithelia with hLIF and CHIR99021 (Li, et al. 2011), as well as the derivation of functional neurons from human pluripotent stem cells (PSCs) (Qi, et al.). Additionally, SB431542 allows for the enhanced differentiation of PSCs into cardiomyocytes (Kattman, et al.).

Cell types: Cardiomyocytes, PSC-Derived, Endothelial Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons
Alternative Names: SB-431542, SB 431542
Applications: Differentiation, Reprogramming

Accelerating Cell Therapy Research Programs

As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents.

GMP Features

• Enhanced quality testing and documentation
• High purity and consistent activity
• Reduce risk of unwanted genetic material
• Easily scalable, available in large volumes
• Manufactured following ICH Q7 guidelines

Quality Assurance

• QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
• Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

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