JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM). SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs).
SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM).
As Smoothened mediates Hedgehog activity, SANT-1 has the potential of affecting cellular patterning through differentiation and proliferation during embryonic development (Chen, et al.). When used in conjunction with CHIR99021, LDN193189, and Y27632, among others, SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.) in addition to the creation of pancreatic progenitors from PSCs (Nostro, et al.).
Keywords: SANT-1, 304909-07-7, SANT1, SANT 1, Smo, Hedgehog Inhibitor
Download this free eBook from Captivate Bio. We’ve compiled information over the years to help you build on a lab program designed to fit your own needs.
PDF | Download our Small Molecules for Cell and Gene Therapy Research flyer. Now offering RUO and GMP-grade small molecules for a variety of cell types.
PDF | Download The Captivate Bio Access Program flyer and learn more about how we can support small and mid-size life science companies who are looking for immediate access to consulting, marketing, and sales programs.
