Retinoic Acid (GMP)

Captivate Bio offers a portfolio of GMP-grade small molecules. GMP-grade small molecules are produced under well establish, controlled cGMP guidelines and are used as ancillary reagents in the generation of stem cells and in reprogramming, self-and differentiation workflows for cell therapy applications.

Retinoic Acid (all-trans) is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors (RARs, specifically RARα/β/γ) with an IC50 of 14nM and has a major effect on the differentiation and patterning of stem cells, and therefore in the development process (Rhinn & Dolle). In the process of differentiating mouse embryonic stem cells (ESCs), Retinoic Acid has been shown to promote the growth of glial cells and functional neurons in culture (Fraichard, et al.).

Furthermore, Retinoic Acid has played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells when combined with CHIR99021, SANT-1, Y27632, Compound E, RepSox, Triiodothyronine Salt, and other growth factors (Pagliuca, et al.).

Accelerating Cell Therapy Research Programs

As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents.

GMP Features

• Enhanced quality testing and documentation
• High purity and consistent activity
• Reduce risk of unwanted genetic material
• Easily scalable, available in large volumes
• Manufactured following ICH Q7 guidelines

Quality Assurance

• QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
• Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

Keywords: Retinoic acid, Retinoic acid supplier, GMP molecules, Endogenous, agonists, PPARdelta, Positive modulators, Retinoid, X, Peroxisome, Proliferator-activating, stem cells, ATRA, trans-retinoic, organoids, Retinal Stem Cells, Neural, cell therapy, ipscs

Documents

• Retinoic Acid Technical Data Sheet
• Retinoic Acid GMP SDS
• Brochure: Small Molecules for Stem Cell Research
• FAQs: General Guide for Small Molecules