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StemRegenin 1 or SR1 (GMP-grade) is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes the expansion human hematopoietic stem cells and the generation of progenitor cells. This product is GMP-grade and can be used in cell and gene therapy research applications. Bulk discounts and custom packaging available.
StemRegenin 1 (SR1) is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes ex vivo expansion of CD34+ human hematopoietic stem cells and the generation of CD34+ hematopoietic progenitor cells from non-human primate induced pluripotent stem cells. SR1 has been shown to collaborate with UM729 in preventing differentiation of acute myeloid leukemia (AML) cells in culture. SR1 also stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells into dendritic cells.
SRI promotes maintenance and expansion of human hematopoietic stem cells in culture (Boitano et al., Csaszar et al.) and stimulates differentiation of CD34+ hematopoietic progenitor cells into functional human dendritic cells (Thordardottir et al.). SRI also promotes hematopoietic differentiation of induced pluripotent stem cells (iPS). (Gori et al.) and collaborates with UM729 in preventing differentiation of AML cells in cancer research (Pabst et al.).
Cell Types: Cancer Cells and Cell Lines, Dendritic Cells, Hematopoietic Stem and Progenitor Cells, Leukemia/Lymphoma Cells, Pluripotent Stem Cells Applications: Differentiation, Expansion
Keywords: StemRegenin 1, StemRegenin 1 supplier, SR1, aryl hydrocarbon, receptors, antagonists, antagonism, AHR, hematopoietic, haematopoietic, stem cells, HSCs, CD34, expansion, HSC, Aryl Hydrocarbon, Receptors, Stem Cell Proliferation, Hematopoietic Cells, cancer research, cell therapy
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