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SANT-1 (GMP)

SANT-1 is a potent antagonist that aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (hPSCs). This product is manufactured under cGMP and is ideal for cell therapy applications.

Grouped product items
SKU	SIZE	PRICE	QTY
SML08BG	10 mg	$1,350.00	- +
SML08KG	50 mg	$3,980.00	- +
SML08DG	100 mg	$6,400.00	- +

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SKU	SML08-GMP
Form	Powder
Grade	GMP-grade
Chemical Name	1-Piperazinamine, N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-
Chemical Formula	C₂₃H₂₇N₅
Molecular Weight	373.49
CAS Number	304909-07-7
PubChem ID	329824548
SMILES	CC1=C(/C=N/N2CCN(CC3=CC=CC=C3)CC2)C(C) =NN1C4=CC=CC=C4
Purity	≥98% (LCMS)
Physical Appearance	White to off-white
Target	Smo, Hedgehog
Shipping	AMB
Storage	-20°C

Small Molecules for Stem Cell Research

Captivate Bio's SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM).

As Smoothened mediates Hedgehog activity, SANT-1 has the potential of affecting cellular patterning through differentiation and proliferation during embryonic development (Chen, et al.). When used in conjunction with CHIR99021, LDN193189, and Y27632, among others, SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.) in addition to the creation of pancreatic progenitors from PSCs (Nostro, et al.).

Accelerating Cell Therapy Research Programs

As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents.

GMP Features

Enhanced quality testing and documentation
High purity and consistent activity
Reduce risk of unwanted genetic material
Easily scalable, available in large volumes
Manufactured following ICH Q7 guidelines

Quality Assurance

QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

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References and Publications

Nostro, et al. 2015. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 4(4): 591-604.
Pagliuca, et al. 2014. Generation of functional human pancreatic β cells in vitro. Cell 159: 428-439.
Chen, et al. 2002. Small molecule modulation of Smoothened activity. PNAS. 99(22): 14071-14076.

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