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Dexamethasone is commonly used to stimulate osteogenic differentiation of mesenchymal stem/stromal cells (MSCs) in vitro.
Dexamethasone is a synthetic glucocorticoid, similar to the natural glucocorticoid hydrocortisone. Dexamethasone has an increased affinity for glucocorticoid receptors when compared to the natural hydrocortisone ligand (Kd = 5 nM vs 17 nM). Dexamethasone has been shown to promote transdifferentiation of hepatocytes from mouse pancreatic cells (Shen et al.) and osteogenic, adipogenic, and chondrogenic differentiation of human mesenchymal cells (Jaiswal et al., Mackay et al., Pittenger et al.). Also promotes the differentiation of mature hepatocytes from mouse and human embryonic stem (ES) cells (Cai et al., Kubo et al.).
Cell types: Mesenchymal Stem and Progenitor Cells, Pancreatic Cells, Pluripotent Stem Cells Applications: Differentiation, Reprogramming
Keywords: Dexamethasone, Dexamethasone supplier, anti-inflammatory, glucocorticoid, RMU, dendritic, cell, differentiation, Small Molecules, Epithelial Cell Biology, Stem Cell Biology
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