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Cyclopamine

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Cyclopamine is a Hedgehog (Hh) pathway antagonist with an IC50 of 46 nM in the Hh cell assay. Cyclopamine is also a selective Smo inhibitor.

Grouped product items
SKUSIZEPRICE QTY
SML26A5 mg
$145.00
- +
SML26B10 mg
$280.00
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SKUSML26
FormPowder
Alternative Names11-Deoxojervine
Chemical Name(3S,3'R,3'aS,6'S,6aS,6bS,7'aR,9R,11aS,11bR)-3',6',10,11b tetramethylspiro[2,3,4,6,6a,6b,7,8,11,11a-decahydro-1H-benzo[a]fluorene-9,2'-3a,4,5,6,7,7a-hexahydro-3H-furo[3,2-b]pyridine]-3-ol
Chemical FormulaC27H41NO2
Molecular Weight411.62
CAS Number4449-51-8
PubChem ID442972
Purity≥ 99%
TargetHedgehog; Endogenous Metabolite; Smo
ShippingAMB

Cyclopamine, is used as a hedgehog [Hh] signaling pathway and Smo inhibitor. It depletes stem-like cancer cells in glioblastoma and blocks tumor engraftment. Can also be used to induce differentiation of human embryonic stem cells (hESCs) into hormone-expressing endocrine cells.

Cycoplamine has been utilized as a small molecule inducer of stem cell differentiation towards definitive endoderm pancreatic islet cells, as a modulator of cell proliferation, and as an anticancer drug.

Cell types: Cancer Cells and Cell Lines, Endoderm, PSC-Derived, Mammary Cells, Neural Stem and Progenitor Cells, Pancreatic Cells, Pluripotent Stem Cells

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References & Publications
  • Peukert S, et al. Bioorg Med Chem Lett, 2009, 19(2), 328-331.
  • Berman DM, et al. Nature, 2003, 425(6960), 846-851.
  • Thayer SP, et al. Nature, 2003, 425(6960), 851-856.
  • Ma W, et al. J Genet Genomics. 2018 May 20;45(5):237-246.
  • Qi Wan, et al. Res. 2020 May 24.
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