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Dorsomorphin is a small molecule widely used in cell culture as a selective inhibitor of BMP signaling. Dorsomorphin is particularly useful in early-stage stem cell differentiation studies to direct cells toward specific lineages, such as cardiac or neural.
Captivate Bio's Dorsomorphin (also known as Compound C) is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki=109nM) and bone morphogenic protein (BMP) signaling. It was identified in a screen for compounds that perturb dorsoventral axis formation in zebrafish. Dorsomorphin functions through inhibition of BMP type I receptors ALK2, ALK3 and ALK6 and thus blocks BMP-mediated SMAD1/5/8 phosphorylation. BMP signaling coordinates developmental patterning and have essential physiological roles in mature organisms. Dorsomorphin has been used to probe BMP signaling in iron-hepcidin homeostasis, cardiomyogenesis and osteogenesis.
Applications: Neural differentiation, inducing cardiomyogenesis, regulating stem cell fate, adipocyte differentiation, human mesenchymal stem cells, cancer research, AMPK Inhibition
Keywords: Dorsomorphin, Compound C, Organoid, Transforming growth factor beta receptors, ATP-competitive BMP type I receptors, AMPK inhibitor
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