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Compound E is a γ-secretase and notch patchway inhibitor which induces neuronal differentiation. Compound E enhances growth inhibition, differentiation, and migration of neuroblastoma cells.
Compound E is a potent γ-secretase inhibitor that specifically blocks β-amyloid-40 (IC50 of 0.24), β-amyloid-42 (IC50 of 0.37), and cleavage of the Notch domain (IC50 of 0.32). Compound E has been shown to promote the differentiation of embryonic stem cells (ESCs) to primitive neural precursors in addition to generating a self-renewing progenitor neuroepithelia stem cell population (Li, et al.) when combined with CHIR99021, SB431542, and hLIF. Forebrain GABA interneurons have also been derived from human pluripotent stem cells (PSCs) through the utilization of Compound E (Liu, et al.); additionally, it has shown promising effects in Alzheimer’s disease models using iPSC-derived neurons (Yagi, et al.).
Alternative names: XXI, Compound E (secretase inhibitor), DuPont E, C-E, γ-secretase inhibitor XXI, Gammasecretase inhibitor XXI, gamma inhibitor Applications:enhances growth inhibition, differentiation of hPSCs Cell types: neural, hPSCs, hESCs
Keywords: Compound E, gamma-secretase, g-secretase, neuronal differentiation, neurons, self renewal, notch pathways, neural stem cells, hPSCs
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