TPPB

TPPB is a high affinity and cell permeable protein kinase C activator (Ki =11.9 nM), which induces differentiation of hESCs into Pdx-1 expressing pancreatic progenitor cells. TPPB also enhances the non-amyloidgenic processing of amyloid precursor protein, increasing secretion of sAPPα.

While these powerful tools are capable of modulating key pathways and targets within a cell, effects can be easily fine-tuned by varying combinations and concentrations. All Captivate Bio’s small molecules are rigorously tested by liquid chromatography and mass spectrometry to guarantee highest purities and chemical structure consistency.

References

• Curreli F, et. al. 2020. Identification of Combinations of Protein Kinase C Activators and Histone Deacetylase Inhibitors That Potently Reactivate Latent HIV. Viruses.
• Rezania, A. et al. 2014. Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells. Nat. Biotechnol.
• Kozikowski AP, et al. 2003. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J Med Chem.
• Yang HQ, et al. 2012. Neuroprotective effects of new protein kinase C activator TPPB against Aβ25-35 induced neurotoxicity in PC12 cells. Neurochem Res.