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Highly potent PORCN inhibitor, Wnt-C59 is used to generate B cells from human PSCs, induce neural differentiation and cardiomyocyte differentiation.
Wnt-C59 is a highly potent inhibitor of the MBOAT (membrane-bound O-acyltranferase) family member, Porcupine (PORCN) (IC50 = 74 pM), that mediates WNT palmitoylation and secretion. Wnt-C59 potently inhibits the processing of both canonical (1, 2, 3a, 6, 7b, 8a, 9a, 9b, 10) and non-canonical (4, 5a, 11, 16) Wnt subtypes. Wnt-C59 blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/β-catenin target genes. Wnt-C59-treated tumors show a decrease in β-catenin, CyclinD1 and c-Myc.
Wnt-C59 induces cardiomyocyte differentiation from human iPSCs following culture with CHIR99021. Wnt-C59 efficiently induces neural differentiation of CTIP2+/COUP-TF1- cells from PSCs in culture. When grafted into the cortex of adult mice, Wnt-C59-treated cells develop abundant axonal fiber extensions toward the spinal cord. The compound has also been used in protocols to generate β cells from human PSCs.
Keywords: Wnt-C59, Wnt-C59 supplier, Highly, potent, inhibitors, inhibits, membrane-bound, Wnt, signaling, pathways, WntC59, PORCN, Cardiomyocyte, ESCs, iPSC, Organoids
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