Kartogenin (KGN)

Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.

Kartogenin is widely used in cell therapy research for cartilage regeneration and protection, tendon-bone healing, wound healing, and limb development. Kartogenin promotes cartilage repair, coordinates limb development, and is also used in osteoarthritis (OA) research.

Applications: Wound healing, tissue engineering
Cell types: Mesenchymal Stem Cells

Keywords: Kartogenin, Smad Transforming growth factor, beta differentiation human mesenchymal stem cells chondrocytes osteoarthritis, Inhibitor, inhibitor, inhibit

References & Publications

• Johnson K, et, al. A stem cell-based approach to cartilage repair. Science. 2012 May 11;336(6082):717-21.
• Liu F, et, al. A novel kartogenin-platelet-rich plasma gel enhances chondrogenesis of bone marrow mesenchymal stem cells in vitro and promotes wounded meniscus healing in vivo. Stem Cell Res Ther. 2019 Jul 8;10(1):201.
• Cai J, Zhang L, Chen J, et al. Kartogenin and its application in regenerative medicine[J]. Current medical science, 2019, 39(1): 16-20.
• Zhang J, Wang J H C. Kartogenin induces cartilage-like tissue formation in tendon–bone junction[J]. Bone research, 2014, 2(1): 1-10.