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Hedgehog pathway activator; Activates Smoothened (SMO). Purmorphamine has been shown to promote differentiation of motor neurons from human pluripotent stem cells and human and mouse mesenchymal stem cells.
The Sartorius MEM-NEAA (100X) solution is added as a supplement to cell culture media which stimulates growth and viability of cells in culture. This product is sold in case packs only.
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells.
IWP 2 is a potent inhibitor of Wnt processing and secretion (IC50 = 27nM). IWP-2 has also been used in protocols to reprogram somatic cells to chemically-induced PSCs.
Y-27632 is a cell-permeable, highly potent and selective inhibitor that Increases survival rates of hESc and iPSCs undergoing cryopreservation. Available in various pack sizes and in RUO and GMP-grade material.
New! Captivate Bio now offers PLUS™ Gamma Irradiated HPL in Cryobags. This product is manufactured and gamma irradiated under cGMP for use in clinical cell culture protocols and available in 250 ml bags.
IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
PD0325901 is a selective, non-ATP-competitive inhibitor of the mitogen-activated protein kinase (MAPK/ERK kinase, or MEK) that suppresses expression of p-ERK1/2 and induces apoptosis. PD0325901 enhances generation of induced pluripotent stem cells (iPSCs).
PLTGold Human Platelet Lysate (GMP grade) is a growth factor rich, xeno-free, heparin-free cell culture supplement that is a superior alternative to FBS. This HPL is pathogen-inactivated, US origin with a FDA Master File.
Emricasan is an irreversible pan-caspase inhibitor. A key small molecule component of the published CEPT cocktail, enhances cell survival, clonogenicity, and cytoprotection of hPSCs.
