Z-VAD-FMK

Z-VAD-FMK is a cell-permeable pan-caspase inhibitor that irreversibly binds to the catalytic site of caspase proteases and can inhibit induction of apoptosis. Z-VAD-FMK has been shown to block TGF-beta1-induced apoptosis and inhibit CPP32-like protease activity in lysates in the pretreatment of hepatocytes.

Features

• Broad-spectrum caspase inhibitor
• Potent inhibitor of caspase-dependent inflammasomes
• Blocks the induction of apoptosis
• Each lot is highly pure (≥95%) and functionally tested

Documents

• Z-VAD-FMK Technical Data Sheet
• Brochure: Small Molecules for Stem Cell Research
• FAQs: General Guide for Small Molecules

References and Publications

• Kawasaki M, et al. (2000) Protection from lethal apoptosis in lipopolysaccharide-induced acute lung injury in mice by a caspase inhibitor. Am J Pathol. 157(2):597- 603.
• Park S, et al. (2004) Neurovascular protection reduces early brain injury after subarachnoid hemorrhage. Stroke. 35(10):2412-7.
• Inayat-Hussain SH, et al. (1997) Processing/activation of CPP32-like proteases is involved in transforming growth factor beta1-induced apoptosis in rat hepatocytes. Hepatology. 25(6):1516-26.