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R-Spondin-1 Protein, Human is a potent activator of the Wnt/β-catenin signaling pathway and a secretory glycoprotein that promotes the proliferation of intestinal stem cells and liver fibrosis studies, used in organoid research. This is a recombinant human RSPO1 protein expressed in CHO cells with a C-6*His tag.
R-Spondin-1, Human (RSPO1) is a potent activator of the Wnt/β-catenin signaling pathway and a secretory glycoprotein belonging to the R-Spondin family. RSPO1 homotetramers synergize with LRP5/6 via LGR4/5/6 and activate the Wnt/β-catenin pathway by inhibiting DKK1/Kremen-mediated LRP6 endocytosis. RSPO1 promotes β-catenin nuclear translocation, drives HSC activation in liver fibrosis, inhibits adipocyte thermogenic gene expression, and promotes intestinal epithelial proliferation. RSPO1/R-spondin-1 Protein, Human (CHO, His) is a recombinant human RSPO1 protein expressed in CHO cells with a C-6*His tag.
Keywords: cristin 3, CRISTIN3, HRspo1, RSPO, RSPO1, RSpondin 1, Roof Plate-specific Spondin 1, organoids, organoid research, liver organoids, kidney, intestinal, stem cells, 3D cultures, R-Spondin1, Organoid culture medium, Wnt/β-catenin signaling pathway, tissue engineering
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