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EC23 (AGN 190205) is a stable synthetic retinoid analogue and induces neuronal differentiation.
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes (EC50 = 100 nM). Reduces disease severity in a mouse model of osteoarthritis; displays protective effects against osteoarthritic stimuli in mature chondrocytes in vitro.
Captivate Bio's MCDB 131 medium is commonly used in definitive endoderm differentiation of human pluripotent stem cells (hPSCs) as well as a basal medium for MSC differentiation.
Medium 199 is widely used in virology and vaccine production. This formulation is modified with Earle's salts and without L-glutamine or HEPES.
Compound E is a γ-secretase and notch patchway inhibitor which induces neuronal differentiation. Compound E enhances growth inhibition, differentiation, and migration of neuroblastoma cells.
RepSox is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox was found to replace the function of Sox2 to induce reprogramming of iPS cells.
A83-01 has been extensively used in various studies to modulate TGF-β signaling pathways, impacting cellular differentiation, organoid growth, and disease modeling. A83-01 is supplied as a lyophilized powder.
DBZ is an inhibitor of γ-secretase aspartyl protease that improves efficiency of iPSC generation and production of iPSCs from mouse and human keratinocytes without KLF4 and CMYC.
Emricasan is an irreversible pan-caspase inhibitor. A key small molecule component of the published CEPT cocktail, enhances cell survival, clonogenicity, and cytoprotection of hPSCs.
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