XAV939 (GMP)

Small Molecules for Stem Cell Research

Captivate Bio offers a portfolio of GMP-grade small molecules. GMP-grade small molecules are produced under well establish, controlled cGMP guidelines and are used as ancillary reagents in the generation of stem cells and in reprogramming, self-and differentiation workflows for cell therapy applications.

XAV939 (GMP-grade) is a tankyrase (TNKS) inhibitor, most specifically for TNKS1 (IC50 of 5nM) and TNKS2 (IC50 of 2nM) (Haikarainen, et al.), in turn indirectly inhibiting downstream Wnt/β-catenin signaling (Huang, et al.). XAV939 has been shown to be an efficient additive in the derivation of functional neurons from human pluripotent stem cells (PSCs) when combined with other small molecules including LDN193189 and SB431542 (Qi, et al.). Additionally, XAV939 allows for the enhanced differentiation of PSCs into cardiomyocytes (Minami, et al.).

Alternative Names: XAV 939, XAV-939
Applications: Differentiation
Cell Types: Cancer Cells and Cell Lines, Cardiomyocytes, PSC-Derived, Neural Cells, PSC-Derived, Pluripotent Stem Cells

Accelerating Cell Therapy Research Programs

As your research program advances into therapeutic applications, making the transition from research-grade to GMP-grade reagents is critical to the success of your project. Captivate Bio can facilitate this transition easier with the availability of both RUO and GMP-grade small molecules that are designed with enhanced quality testing and are suitable for use as ancillary reagents.

GMP Features

• Enhanced quality testing and documentation
• High purity and consistent activity
• Reduce risk of unwanted genetic material
• Easily scalable, available in large volumes
• Manufactured following ICH Q7 guidelines

Quality Assurance

• QC tests include: purity, water content, residual solvents, bioburden, endotoxin, elemental impurities, and solubility
• Documentation includes: Certificate of Analysis (CoA), Safety Data Sheet (SDS), Certificate of Origin (CoO), TSE/BSE Statement, Technical Data Sheet, and Declaration of GMP Compliance

Keywords: XAV-939 (GMP), 284028-89-3, PARP, poly ADP, ribose, polymerasemid, brain dopamine (mDA), human pluripotent stem cells, hpscs, ipscs,

Documents

• XAV939 Technical Data Sheet
• XAV939 SDS
• Brochure: Small Molecules for Stem Cell Research
• FAQs: General Guide for Small Molecules

References and Publications

• Jung, YS., et al. 2020. Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complexExp Mol Med 52, 183–191.
• Qi, et al. 2017. Combined small-molecule inhibition accelerations the derivation of functional cortical neurons from human pluripotent stem cells. Nature Biotechnology.
• Haikarainen, et al. 2014. Tankyrases: structure, function, and therapeutic implications in cancer.Curr Pharm Des.
• Minami, et al. 2012. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Reports.
• Wang, et al. 2010. Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem. Biol.
• Huang, et al. 2009. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature.