TGF-beta 1, Human, HEK293

TGF-beta 1 (transforming growth factor beta 1, TGF-β 1) is a member of the TGF-β superfamily, released from degranulating platelets and secreted by all major cell types involved in tissue repair, including lymphocytes, macrophages, smooth muscle cells, endothelial cells, epithelial cells, and fibroblasts. TGF-beta 1 is the most predominant of the three isoforms (TGF-β 1, TGF-β 2, TGF-β 3).

TGF-beta 1 protein regulates cell proliferation, growth, movement, and differentiation. Endogenous TGF-beta 1 inhibits the cell cycle in the G1 phase, controlling apoptosis in normal and pathological tissues.

Recombinant human TGF-beta 1 protein is used with bFGF to support the culture and maintenance of undifferentiated human pluripotent stem cells (hPSCs). Cell signaling via TGF-beta 1 regulates a variety of diverse cellular phenotypes and functions, including metabolism, proliferation, differentiation, fibrogenesis, and immune cell homeostasis.

TGF-beta 1 protein binds to serine-threonine kinase type I and II receptors to activate signal transduction through SMAD2/3 pathways.

Cross-reactivity: Mouse, rat, cow, dog, pig, horse

Applications: Pluripotent stem cell (hPSC) culture, pluripotency maintenance, differentiation, mesenchymal stem cell (MSC) culture, neural cell culture, immunology

Cell types: Pluripotent stem cells, iPSCs, ESCs, MSC, neural stem and progenitor cells, T cells, B cells, monocytes

Features & Benefits

• Recombinant human protein expressed in human cells (HEK293)
• Improved activity and stability gained from native protein post-translational modifications and maturation
• Matched GMP version available

Documents

• Recombinant Proteins Product Information Sheet