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IL-21 Protein, Human is produced by activated CD4+ T cells. IL-21 Protein stimulation of T cells, B cells and NK cells leads to enhanced proliferation and mature effector function.
Interleukin-21 (IL-21), a potent immunomodulatory four-alpha-helical-bundle type I cytokine. IL-21 is a cytokine involved in the development and pathogenesis of autoimmune diseases. IL-21 is normally expressed by activated CD4+ T cells and is aberrantly expressed in Hodgkin lymphoma cells. The IL-21 receptor (IL-21R) activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. Within the B cell lineage, IL-21 is a switch factor regulating IgG1 and IgG3 antibody production. IL-21 also cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
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