HGF Protein, Human, CHO

Human hepatocyte growth factor (HGF) is a natural ligand of Met tyrosine kinase receptor, mediating cell proliferation, migration and anti-apoptosis by binding to Met receptor. HGF protein can promote the regeneration of liver and kidney cells, regulate extracellular matrix metabolism (inhibit TGF-β, promote MMP-2), and is used in the study of acute and chronic kidney disease, liver fibrosis and other diseases. HGF Protein, Human is a recombinant human HGF protein expressed by CHO cells with tag-free.

Applications
HGF can be used in the study of acute kidney injury (AKI), chronic kidney disease (CKD) and diabetic nephropathy. It can inhibit the increase of blood urea nitrogen (BUN) in kidney disease models, reduce tubular damage and glomerular sclerosis, and renal damage does not affect its pharmacokinetics. HGF also promotes liver regeneration (such as acute liver failure and liver fibrosis), and can enhance liver repair and improve liver function when combined with bone marrow mononuclear cells (BMMCs). HGF also alleviates glomerular and liver tissue fibrosis by inhibiting excessive deposition of TGF-β and ECM; it promotes cell migration and differentiation, and exerts anti-fibrotic activity. In clinical studies, recombinant human HGF protein has entered Phase I clinical trials for fulminant hepatitis.