JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Thermostable bFGF recombinant human protein. Engineered recombinant fibroblast growth factor-2 (bFGF, FGF2, FGF basic) designed for improved thermostability of the protein in cell culture media.
bFGF (K128N) is an engineered recombinant human fibroblast growth factor 2 protein (FGF2) with a K128N point mutation designed to improve thermostability of the protein in cell culture media. bFGF (K128N) protein enables weekend-free and/or reduced feeding schedules for human pluripotent stem cell (hPSC) cultures over the unstable wildtype bFGF protein. The improved stability of bFGF (K128N) efficiently maintains a more homogeneous undifferentiated cell culture population, and is a cost-effective supplement allowing for less-frequent media changes. This protein has also been published as FGF2-K128N.
Fibroblast growth factor-basic (bFGF, FGF basic, FGF2) is a key protein many biological processes for a variety of cell types, such as maintenance and self-renewal, proliferation, differentiation, survival, apoptosis, angiogenesis, wound healing, and tissue repair.
bFGF is an essential growth factor for the maintenance of undifferentiated human pluripotent stem cells (hPSC) in culture and support of pluripotency induction in reprogramming pathways. bFGF is critical an many other stem cell pathways, including differentiation of neural rosette differentiation from hPSCs, as well as enhanced proliferation of human mesenchymal stem cells (MSC) and differentiation to the chondrogenic lineage.
Applications: Pluripotent stem cell culture, reprogramming, differentiation, mesenchymal stem cell culture
Cell types: Pluripotent stem cells, iPSCs, ESCs, mesenchymal stem cells, MSCs, neural cells
bFGF has a beta-trefoil structure and binds to the four FGF receptors (FGFR) to activate JAK/STAT, PI3K, ERK1/2, and other receptor tyrosine kinase (RTK) pathways.
PDF | Download Captivate Bio's new labware products flyer highlighting our NEST cell culture flasks, dishes, multwell plates, centrifuge tubes, bioprocessing tools and more.
PDF | Download Captivate Bio's 2024 New Products & Services brochure. Highlighting new reagent sourcing, storage services, salt solutions, water, cytokines and growth factors to support life science research.
PDF | EverCell Bio and Captivate Bio have teamed up to provide a single source solution for stem cell modeling services and ongoing product support to accelerate translational and therapeutic discoveries. Download our brochure here.