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Thiazovivin

Thiazovivin is a novel ROCK inhibitor with IC50 of 0.5 μM in a cell-free assay, promotes hESC survival after single-cell dissociation. Improves the efficiency of fibroblast reprogramming and induction of iPSCs.

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SML10B 10 mg $165.00
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SKUSML10B
Size10 mg
Molecular NameThiazovivin, ROCK inhibitor
Size10 mg
FormPowder
Alternative NamesROCK, RHO/ROCK
Chemical Name4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)-
Chemical FormulaC15H13N5OS
Molecular Weight311.36
CAS Number1226056-71-8
PurityGreater than 95% by LCMS
Physical AppearanceWhite to brown (Solid)
Shelf-LifeStore at -20°C
Storage≥ 2 years

Thiazovivin is a potent and selective inhibitor of Rho kinase (ROCK) activity, a key player in cytoskeletal contraction and rearrangement. As ROCK inhibition occurs, human embryonic stem cell survival increases through enhanced cell-ECM attachment via E-cadherin signaling (Xu, et al.), in addition to allowing for an environment for improved human iPSCs from fibroblasts when used in combination with ALK5 inhibitor SB 431542 and MEK inhibitor PD0325901 (Lin, et al.). The addition of Thiazovivin also creates more effective conditions for the reprogramming of cord blood mononuclear cells into iPSCs (Hu, et al.).

Applications: cellular reprogramming, mouse embryonic fibroblasts into chemically induced neural stem cells, improves the efficiency of iPSC generation
Molecular name: Thiazovivin, ROCK inhibitor
Purity: Greater than 95% by LCMS

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