Compound E Small Molecule

Compound E

LDN193189 (HCl) Small Molecule

LDN193189 (4HCl)

Thiazovivin

$165.00
In stock
SKU
SML10B
Thiazovivin is a potent and selective inhibitor of Rho kinase (ROCK) activity, a key player in cytoskeletal contraction and rearrangement. As ROCK inhibition occurs, human embryonic stem cell survival increases through enhanced cell-ECM attachment via E-cadherin signaling (Xu, et al.), in addition to allowing for an environment for improved human iPSCs from fibroblasts when used in combination with ALK5 inhibitor SB 431542 and MEK inhibitor PD0325901 (Lin, et al.). The addition of Thiazovivin also creates more effective conditions for the reprogramming of cord blood mononuclear cells into iPSCs (Hu, et al.).
Specifications
Molecular NameThiazovivin, ROCK inhibitor
Size10 mg
FormPowder
Alternative NamesROCK, RHO/ROCK
Chemical Name4-Thiazolecarboxamide, N-(phenylmethyl)-2-(4-pyrimidinylamino)-
Chemical FormulaC15H13N5OS
Molecular Weight311.36
CAS Number1226056-71-8
PurityGreater than 95% by LCMS
Physical AppearanceWhite to brown (Solid)
Shelf-LifeStore at -20°C
Storage≥ 2 years
Documents

Thiazovivin Technical Data Sheet

Thiazovivin SDS

Brochure: Small Molecules for Stem Cell Research

FAQs: General Guide for Small Molecules

References and Publications

Hu, et al. 2011. Efficient generation of transgene-free induced pluripotent stem cells from normal and neoplastic bone marrow and cord blood mononuclear cells. Blood. 117(14): 109-119.

Lin, et al. 2009. A chemical platform for improved induction of human iPSCs. Nature Methods. 6: 805-808.

Xu, et al. 2010. Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.

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