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An integrated stress response (ISR) inhibitor that promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 and Emricasan small molecules in the CEPT cocktail¹.

Captivate Bio's DMEM/F12 basal medium is typically used as a classical basal formulation in low-serum and serum-free media formulations, when culturing hPSCs and 3D organoids. This formulation is with L-glutamine and Phenol Red.

Captivate Bio's DMEM, High Glucose is a widely used basal medium for supporting the growth of many different mammalian cells. This formulation contains 4500 mg/L glucose and no L-glutamine.

Captivate Bio's DMEM, High Glucose is a widely used basal medium for supporting the growth of many different mammalian cells. This formulation contains 4500 mg/L glucose, no L-glutamine, and no Phenol Red.

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

CHIR99021 potentiates self-renewal of human and mouse embryonic stem cells and enhances reprogramming of somatic cells into stem cells and also augments the differentiation potential of MSCs. Available as a lyophilized powder and in RUO or GMP-grade formats.

Emricasan is an irreversible pan-caspase inhibitor. A key small molecule component of the published CEPT cocktail, enhances cell survival, clonogenicity, and cytoprotection of hPSCs.

Captivate Bio's EMEM, without L-glutamine is a commonly used basal media for a variety of suspension and adherent mammalian cells. This formulation is configured without L-glutamine.

Captivate Bio's EMEM, with L-glutamine is a commonly used basal media for a variety of suspension and adherent mammalian cells. This formulation is configured with L-glutamine.

Triiodothyronine Salt is an analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1). Regulates functions such as growth, metabolic activity, and hPSC differentiation. Stimulates respiratory activity at the mitochondrial level.