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Chroman 1 is a more effective ROCK inhibitor shown to improve cell survival and recovery of hPSCs after cryopreservation. Learn how Chroman 1 compares to Y-27632 in cultures in this short blog post.
May 3, 2024 – Captivate Bio announces new distribution agreement with NEST Scientific USA. With over 200 new products added to its portfolio, Captivate Bio will distribute NEST branded labware to the North American market.
When used to enhance hPSC survival and clonal expansion during passaging, Trans-ISRIB is used at a final concentration of 0.7 µM in cell culture media.
Prepare a concentrated stock solution of Chroman 1 by reconstituting the lyophilized powder with DMSO to the appropriate stock concentration. Generally a 1,000X or 10,000X concentrated stock solution is useful, depending on the desired final concentration and application.
Chroman 1 is a highly potent and selective small molecule ROCK inhibitor (both ROCK 1 and ROCK 2), with greater effectiveness at lower doses than Y27632. Chroman 1 has been shown to improve survival of human pluripotent stem cells and enhance recovery of cells after cryopreservation.
When used to enhance hPSC survival and clonal expansion during passaging, Emricasan is used at a final concentration of 5 µM in cell culture media.
