CHIR99021 Small Molecule

CHIR99021

XAV939 Small Molecule

XAV939

Y27632 (2HCl)

Y-27632 is a cell-permeable, highly potent and selective inhibitor of Rho-associated, coiled-coil containing protein kinase (ROCK).
Size: 10 mg
$125.00
In stock
SKU
SML13B
Small Molecules for Stem Cell Research

Y-27632 is a common research tool used in the field of stem cell research for maintenance, differentiation, and the survival of cells following cryopreservation. Y-27632 is also used as 3D growth matrix component and included in brain organoid differentiation media.

Y-27632 dihydrochloride is a highly specific inhibitor of Rho-associated coiled-coil protein kinase (ROCK) activity as a cell-permeable, ATP-competitive inhibitor of both ROCK1 (Ki of 220 nM) and ROCK2 (Ki 300 nM) (Ishizaki, et al.). Human embryonic stem cell (ESC) survival is improved through enhanced attachment following single cell dissociation, cryopreservation, and FACS sorting in both feeder-dependent and -independent cultures (Emre, et al.). This enhanced cell attachment, and thus recovery, is boosted through decreased dissociation-induced apoptosis (Watanabe, et al.). Y-27632 dihydrochloride primes human induced pluripotent stem cells (iPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.

Alternative names: Y-27632 dihydrochloride, Y-27632, ROCK inhibitor, Y27632, Rho kinase inhibitor
Applications: Differentiation, cryopreservation, expansion, maintenance, reprogramming, spheroid Culture
Cell types: Neurons, Pluripotent Stem Cells, iPSCs, ESCs

Features & Benefits
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Specifications
Molecular NameY-27632 (2HCl)
Size10 mg
FormPowder
Alternative NamesY-27632 dihydrochloride, Y-27632, ROCK inhibitor, Y27632, Rho kinase inhibitor
Chemical Name4-[(1R)-1-aminoethyl]-N-4-pyridinyl-trans-cyclohexanecarboxamide, dihydrochloride
Chemical FormulaC14H23Cl2N3O
Molecular Weight320.26
CAS Number129830-38-2
PubChem ID9901617
PurityGreater than 95% by HPLC
Physical AppearanceWhite to off-white (Solid)
Shelf-Life≥ 2 years (powder)
ShippingRoom Temperature
StorageStore at -20°C
Quality StatementThis product is for Research Use Only and is not intended for therapeutic or diagnostic use.
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