Small Molecules for Stem Cell Research
XAV939 is a tankyrase (TNKS) inhibitor, most specifically for TNKS1 (IC50 of 5nM) and TNKS2 (IC50 of 2nM) (Haikarainen, et al.), in turn indirectly inhibiting downstream Wnt/β-catenin signaling (Huang, et al.). XAV939 has been shown to be an efficient additive in the derivation of functional neurons from human pluripotent stem cells (PSCs) when combined with other small molecules including LDN193189 and SB431542 (Qi, et al.). Additionally, XAV939 allows for the enhanced differentiation of PSCs into cardiomyocytes (Minami, et al.).
|Molecular Name||XAV939, Tankyrase inhibitor|
|Alternative Names||XAV 939, XAV-939|
|Chemical Name||4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4- (trifluoromethyl)phenyl]-|
|Purity||Greater than 95% by LCMS|
|Physical Appearance||White to off-white (Solid)|
|Target||β-catenin, PARP, TNK|
|Shelf-Life||≥ 2 years (powder)|
|Storage||Store at -20°C|
References and Publications
Jung, YS., et al. 2020. Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complexExp Mol Med 52, 183–191.
Qi, et al. 2017. Combined small-molecule inhibition accelerations the derivation of functional cortical neurons from human pluripotent stem cells. Nature Biotechnology.
Haikarainen, et al. 2014. Tankyrases: structure, function, and therapeutic implications in cancer.Curr Pharm Des.
Wang, et al. 2010. Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling. ACS Chem. Biol.
Huang, et al. 2009. Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling. Nature.