Y27632 (2HCl) Small Molecule

Y27632 (2HCl)

Compound E Small Molecule

Compound E


In stock
Small Molecules for Stem Cell Research

XAV939 is a tankyrase (TNKS) inhibitor, most specifically for TNKS1 (IC50 of 5nM) and TNKS2 (IC50 of 2nM) (Haikarainen, et al.), in turn indirectly inhibiting downstream Wnt/β-catenin signaling (Huang, et al.). XAV939 has been shown to be an efficient additive in the derivation of functional neurons from human pluripotent stem cells (PSCs) when combined with other small molecules including LDN193189 and SB431542 (Qi, et al.). Additionally, XAV939 allows for the enhanced differentiation of PSCs into cardiomyocytes (Minami, et al.).

Size10 mg
Molecular NameXAV939, Tankyrase inhibitor
Size10 mg
Alternative NamesXAV 939, XAV-939
Chemical Name4H-Thiopyrano[4,3-d]pyrimidin-4-one, 3,5,7,8-tetrahydro-2-[4- (trifluoromethyl)phenyl]-
Chemical FormulaC14H11F3N2OS
Molecular Weight312.31
CAS Number284028-89-3
PubChem ID135418940
PurityGreater than 95% by LCMS
Physical AppearanceWhite to off-white (Solid)
Targetβ-catenin, PARP, TNK
Shelf-Life≥ 2 years (powder)
StorageStore at -20°C
Write Your Own Review
Only registered users can write reviews. Please Sign in or create an account