LDN193189 (HCl) Small Molecule

LDN193189 (4HCl)

Retinoic Acid Small Molecule

Retinoic Acid

Triiodothyronine Salt

$150.00
In stock
SKU
SML11F
Small Molecules for Stem Cell Research
Triiodothyronine Salt (or Liothyronine sodium/3,3’,5-Triiodo-L-thyronine sodium) is an analog of thyroid hormone that selectively binds to and activates β1 thyroid hormone receptor (TRβ1). This binding, in turn, regulates functions such as growth, metabolic activity, and differentiation (Bhat, et al.). Triiodothyronine Salt has been shown to promote enhanced maturation of cardiomyocyte populations, to the extent that beating cardiomyocytes may be maintained for up to six months (Burridge, et al.), in addition to playing a role in the induction of pluripotent stem cells from human keratinocytes (Aasen & Belmonte).
Specifications
Molecular NameSML11F
Size500 mg
FormPowder
Alternative NamesLiothyronine Sodium, 3,3’,5-Triiodo-L-thyronine sodium, T3 Sodium Salt, 3,3',5-Triiodothyronine, Liothyronine, T3 Thyroid Hormone, Triiodothyronine
Chemical NameL-Tyrosine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-, sodium salt (1:1)
Chemical FormulaC15H11I3NNaO4
Molecular Weight672.96
CAS Number55-06-1
PurityGreater than 95% by LCMS
Physical AppearanceOff-white to gray (Solid)
TargetThyroid Hormone Receptor (TRβ1)
Shelf-Life≥ 2 years (powder)
ShippingRoom Temperature
StorageStore at -20°C
Quality StatementThis product is for Research Use Only and is not intended for therapeutic or diagnostic use.
Documents

Triiodothyronine Salt Technical Data Sheet

Triiodothyronine Salt SDS

Brochure: Small Molecules for Stem Cell Research

FAQs: General Guide for Small Molecules

References and Publications

Aasen & Belmonte. 2010. Isolation and cultivation of human keratinocytes from skin or plucked hair for the generation of induced pluripotent stem cells. Nature Protocols. 5: 371-382.

Bhat, et al. 1993. Conformational changes of human β1 thyroid hormone receptor induced by binding of 3,3’,5-Triiodo-L-thyronine. BiochemBiophys Res Commun. 195(1): 385-392.

Burridge, et al. 2015. Chemically defined culture and cardiomyocyte differentiation of human pluripotent stem cells. Curr Protoc Hum Genet. 87(1): 1-15.

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