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SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM). SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs).

An integrated stress response (ISR) inhibitor that promotes survival of pluripotent stem cells in culture when used in combination with Chroman 1 and Emricasan small molecules in the CEPT cocktail¹.

PD0325901 (GMP-grade) is a potent, selective, and orally available inhibitor of MEK1/2, a protein crucial for the MAPK signaling pathway that regulates cell growth and proliferation. This small molecule is produced under cGMP and is ideal for cell therapy applications.

TPPB is a small molecule activator of protein kinase C, also known as α-amyloid precursor protein (APP) modulator or TBP.

BIO is a potent ATP-competitive GSK-3 inhibitor that maintains self-renewal and pluripotency in hESCs, also promotes proliferation and differentiation in cardiomyocytes. Lyophilized powder.

LDN193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor. LDN193189 is a potent inhibitor of the bone morphogenetic (BMP) pathway, shown to contribute to the differentiation of pluripotent stem cells into functional pancreatic beta cells.

IWP 4 is a potent inhibitor of Wnt/β-catenin signaling (IC50 = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.

Retinoic Acid (GMP-grade) is used for the differentiation of embryonic stem cells into motor neurons and human pluripotent stem cells (PSCs) into functional pancreatic β cells. This small molecule is produced under cGMP guidelines and is ideal for cell therapy applications.

CHIR99021 potentiates self-renewal of human and mouse embryonic stem cells and enhances reprogramming of somatic cells into stem cells and also augments the differentiation potential of MSCs. Available as a lyophilized powder and in RUO or GMP-grade formats.

StemRegenin 1 or SR1 is an antagonist of the aryl hydrocarbon receptor (AHR). SR1 promotes the expansion human hematopoietic stem cells and the generation of progenitor cells. This small molecule is available in custom pack sizes.