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SB431542 is a potent small molecule inhibitor of TGF-β signaling. Used for hESC neural differentiation and enhanced differentiation of PSCs into cardiomyocytes. Replaces SOX2 in reprogramming of fibroblasts into iPSCs.
SB431542 is a highly-potent and -selective inhibitor of the TGF-β type I receptor, with specific inhibition of ALK5 (IC50 of 94 nM) and its closest relatives ALK4 and ALK7 as part of the TGF-β/Activin/Nodal pathway. SB431542 has been shown to be a highly efficient additive for inducing neural differentiation of embryonic stem cells (ESCs) in a rapid manner when combined with Noggin (Chambers, et al.), or Noggin and LDN193189 (Edri, et al.), promoting the self-renewal of primitive neuroepithelia with hLIF and CHIR99021 (Li, et al. 2011), as well as the derivation of functional neurons from human pluripotent stem cells (PSCs) (Qi, et al.). Additionally, SB431542 allows for the enhanced differentiation of PSCs into cardiomyocytes (Kattman, et al.).
PDF | Download Captivate Bio's 2024 New Products & Services brochure. Highlighting new reagent sourcing, storage services, salt solutions, water, cytokines and growth factors to support life science research.
PDF | EverCell Bio and Captivate Bio have teamed up to provide a single source solution for stem cell modeling services and ongoing product support to accelerate translational and therapeutic discoveries. Download our brochure here.
This research spotlight highlights the superior cryoprotective capacity of the CEPT method and the survival and functionality of preserved hPSCs.