Small Molecules for Stem Cell Research
SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM). As Smoothened mediates Hedgehog activity, SANT-1 has the potential of affecting cellular patterning through differentiation and proliferation during embryonic development (Chen, et al.). When used in conjunction with CHIR99021, LDN193189, and Y27632, among others, SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.) in addition to the creation of pancreatic progenitors from PSCs (Nostro, et al.).
|Alternative Names||Shh signaling antagonist V|
|Purity||Greater than 95% by LCMS|
|Physical Appearance||White to off-white (Solid)|
|Target||Smoothened (Smo), Hedgehog (Hh)|
|Shelf-Life||≥ 2 years (powder)|
|Storage||Store at -20°C|
|Quality Statement||This product is for Research Use Only and is not intended for therapeutic or diagnostic use.|
References and Publications
Nostro, et al. 2015. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 4(4): 591-604.
Pagliuca, et al. 2014. Generation of functional human pancreatic β cells in vitro. Cell 159: 428-439.
Chen, et al. 2002. Small molecule modulation of Smoothened activity. PNAS. 99(22): 14071-14076.