SB431542 Small Molecule





In stock
Small Molecules for Stem Cell Research

SANT-1 is a potent antagonist of Smoothened (Smo), which in turn inhibits Hedgehog (Hh) signaling, specifically targeting Shh-LIGHT2 (IC50 of 20nM) and SmoA1-LIGHT2 (IC50 of 30nM). As Smoothened mediates Hedgehog activity, SANT-1 has the potential of affecting cellular patterning through differentiation and proliferation during embryonic development (Chen, et al.). When used in conjunction with CHIR99021, LDN193189, and Y27632, among others, SANT-1 aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.) in addition to the creation of pancreatic progenitors from PSCs (Nostro, et al.).

Size10 mg
Molecular NameSANT-1
Size10 mg
Alternative NamesShh signaling antagonist V
Chemical NameN-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine
Chemical FormulaC23H27N5
Molecular Weight373.49
CAS Number304909-07-7
PurityGreater than 95% by LCMS
Physical AppearanceWhite to off-white (Solid)
TargetSmoothened (Smo), Hedgehog (Hh)
Shelf-Life≥ 2 years (powder)
ShippingRoom Temperature
StorageStore at -20°C
Quality StatementThis product is for Research Use Only and is not intended for therapeutic or diagnostic use.
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