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Retinoic Acid is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors. Retinoic acid has been used for the differentiation of embryonic stem cells into motor neurons and has also played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells.
Retinoic Acid (all-trans) is a metabolite of vitamin A that acts as a ligand for nuclear retinoic acid receptors (RARs, specifically RARα/β/γ) with an IC50 of 14nM and has a major effect on the differentiation and patterning of stem cells, and therefore in the development process (Rhinn & Dolle). In the process of differentiating mouse embryonic stem cells (ESCs), Retinoic Acid has been shown to promote the growth of glial cells and functional neurons in culture (Fraichard, et al.).
Furthermore, Retinoic Acid has played an important role in protocols involving the differentiation of human pluripotent stem cells (PSCs) into functional pancreatic β cells when combined with CHIR99021, SANT-1, Y27632, Compound E, RepSox, Triiodothyronine Salt, and other growth factors (Pagliuca, et al.).
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This research spotlight highlights the superior cryoprotective capacity of the CEPT method and the survival and functionality of preserved hPSCs.
