Retinoic Acid Small Molecule

Retinoic Acid

IWP-2 Small Molecule

IWP-2

RepSox

$125.00
In stock
SKU
SML06B
Small Molecules for Stem Cell Research

RepSox is a potent and selective inhibitor of the TGF-β type 1 receptor (TGFβRI)/ALK5 that exhibits cell permeability and specifically inhibits ALK5 autophosphorylation with IC50 of 4 nM. When used in conjunction with CHIR99021, LDN193189, and Y27632, among others, RepSox aids in the generation of functional human pancreatic beta cells from human pluripotent stem cells (PSCs) (Pagliuca, et al.). RepSox has also been shown to contribute to the reprogramming of mouse embryonic fibroblasts to iPSCs (Subramanyam, et al.), in addition to the induction of human fibroblasts into neuronal cells for research on Alzheimer’s disease (Hu, et al).

Specifications
Size10 mg
Molecular NameRepSox
Size10 mg
FormPowder
Alternative NamesALK5 inhibitor II, ALK5 Inhibitor, ALK5i, E-616452, SJN2511
Chemical Name2-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
Chemical FormulaC17H13N5
Molecular Weight287.32
CAS Number446859-33-2
PurityGreater than 95% by LCMS
Physical AppearanceLight yellow to yellow (Solid)
TargetTGF-β Receptor
Shelf-Life≥ 2 years (powder)
ShippingRoom Temperature
StorageStore at -20°C
Quality StatementThis product is for Research Use Only and is not intended for therapeutic or diagnostic use.
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