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Small Molecules
BOGO on select cell culture products

Small Molecules

A growing number of small molecules have been identified to maintain the self-renewal potential of stem cells, to induce lineage differentiation, facilitate cellular reprogramming, and support cell cryopreservation across a wide range of applications including 3D modeling as well as cancer, diabetes, neuronal, and cardiovascular research.

Captivate Bio’s portfolio of small molecules for stem cell research are powerful tools capable of modulating and fine-tuning key pathways and targets within a cell. All our small molecules are rigorously tested and third-party validated.

Captivate Bio small molecules for hpsc stem cell research

Application Spotlights

small molecules for iPSC diabetes research

Diabetes Research

A scalable differentiation protocol to derive functional insulin-producing beta cells from hPSCs published by Pagliuca, et al. (2014) presents a sixstage protocol using a combination of multiple small molecules and growth factors has shown promise in ameliorating hyperglycemia in mice.

Product highlights: CHIR99021, Retinoic Acid, LDN193189, Sant 1, Triiodothyronine, Y27632

small molecules for iPSC neuronal research

Neural Research

Qi, et al. (2017) describes a protocol in which a cocktail of seven small molecules allows for the creation of cortical neurons capable of producing long-range axonal projections. These cells begin to show mature neural characteristics in just 16 days, and later become fully functional.

Product highlights: DAPT, LDN193189, SB431542, PD0325901, XAV939, Y27632

small molecules for iPSC cardio research

Cardiovascular Research

Noor, et al. (2019) utilized hiPSCs differentiation protocols published by Edri, et al. (2018) and Lian, et al. (2012) for the modeling of 3D vascularized and perfusable heart patches to ultimately be applied to personalized cardiac models and drug screening applications.

Product highlights: CHIR99021, IWP-2, IWP-4, Retinoic Acid, SB203580, Thiazovivin

Minimize cellular stress with Captivate Bio’s CET Cocktail

Captivate Bio’s CET Cocktail pack is comprised of the small molecules used in the CEPT method: Chroman 1Emricasan, and Trans-IRIB (CET). The CEPT method is a published combination of targeted small molecules and culture additives proven to enhance stem cell survival and address the key challenges in translational stem cell research. The CET Cocktail pack provides comprehensive cytoprotection to overcome cellular stressors inherent in stem cell workflows.

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empowering scientific discovery

Captivate Bio’s 2024
Product & Services Catalog

Building on our commitment to offering reliable cell culture solutions for life science research. Download our catalog to learn about all the ways we can help move your research forward.