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myMATRIX MSC is a chemically defined, serum-free, cell adhesion-promoting surface formulated for the expansion of mesenchymal stromal cells. Mimics adhesion proteins such as fibronectin and collagen. Flasks are ready-to-use and sold 5 units per pack.
myMATRIX MSC is a chemically defined cell adhesion-promoting microenvironment specially formulated for the expansion of MSCs. Offered as pre-coated cultureware, myMATRIX synthetic coatings recapitulate the major functions of the natural ECM environment, making cell culture easy, robust, and biologically relevant.
myMATRIX MSC can be used in combination with a variety of dissociation reagents, media and supplements for the support of cell adhesion, rapid proliferation and high viability in serum-containing as well as serum-free culture conditions. The chemically defined nature of the myMATRIX coating qualifies it for the use in cell-based therapies, tissue engineering, drug screening, disease modeling and cell manufacturing for clinical research.
denovoMATRIX technologies are designed to enable the functional recreation of any extracellular matrix (ECM) based on any cell type or application in vitro by providing modular, biomimetic coating technology on your choice of cultureware. myMATRIX MSC is available as pre-coated plates and flasks, bulk inquiries and customization is also available to accommodate your choice of coating and plasticware.
Figure 1. Cell doubling and population comparison. Bone marrow-derived hMSC grown on myMATRIX MSC or tissue culture treated plastic in serum-containing or serum-free medium. Using myMATRIX MSC results in shorter doubling times (in hours (h), left) and higher cumulative population doublings (right).
myMATRIX MSC supports the use of a variety of cell detachment solutions including Dispase, Trypsin, trypsin/EDTA, TrypLE™, and Accutase. For use with hMSC, we recommend using 0.5% Trypsin/EDTA or TrypLE Express Enzyme, and keeping incubation times below 5 minutes to minimize cell stress.
A seeding density of 3.000-8.000 cells/cm2 is recommended. The cells should be sub-cultured upon reaching 80-90% confluence. Optimal seeding densities should be determined by the user since seeding densities can vary based on donor, tissue source, and medium used.
In contrast to other surface coatings, myMATRIX MSC is a biomimetic product, which has been specifically designed to support the expansion of human mesenchymal stromal cells (hMSCs). Although myMATRIX MSC has been designed for hMSCs, it may also support the attachment and proliferation of other adherent cell types.MSCs that have been shown to adhere and proliferate on myMATRIX MSC over the course of at least 3 passages include umbilical cord-derived, adipose-derived, and bone marrow-derived MSCs.
The myMATRIX MSC is chemically defined and free of any human or animal components. myMATRIX MSC enables the expansion of hMSC in xeno-free culture conditions using commercially available xeno-free media and supplements including StemPro™, NutriStem® MSC Medium, StemMACS™ Expansion Medium, as well as human platelet lysate.
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